G protein-coupled receptors (GPCRs) are among the most important signal transducers in physiology and drug discovery, yet many receptors remain orphan, with their endogenous ligands still unknown. In this work, we established a generalizable photo-cross-linking-assisted GPCR deorphanization platform...

We’re very happy to share that Chenyu has successfully passed her PhD thesis defense!During her PhD, Chenyu did fantastic work exploring the in vivo signaling of chemokines with our newly developed fluorescent sensor. Her main thesis project was published in Immunity, and she also played an importan...

Chemokines are a class of extracellular guidance cues that are critical for the migration of cells during development and inflammation. However, there precise spatiotemporal distribution in the native in vivo context has been poorly characterized due to their limited detection methods. Using the GPC...