2022-02-20
The function of extracellular ATP has long been debating, due primary to the lack of sensitive tools to precisely characterize its dynamics in vivo. Recently, we collaborated with Li lab at Peking University to develop and characterized a new genetically encoded GRAB sensor, which could report ATP dynamics in real time with ultrahigh sensitivity and kinetics! Using in vivo systemic inflammation as a model, we also revealed that ATP exhibits spatial-temporal selective releasing pattern and correlates with the brain inflammatory status. Check our latest work and welcome to use that for your own research!
